The INFN National Laboratory of Frascati (LNF) was founded in 1954 with the objective of furthering particle physics research, and more specifically to host the 1.1 GeV electrosynchrotron, the first accelerator ever built in Italy.

[1] The Laboratory later developed the first ever electron-positron collider: from the first prototype AdA, which demonstrated the feasibility, to the ring ADONE and later on to DAΦNE, still operative today (2024).

Besides conducting experiments with their own facilities, the LNF researchers are also taking part in extensive collaborations at external laboratories, especially at CERN and in the United States.

During a seminar in 1960, Bruno Touschek proposed the idea of injecting in the same ring beams of electrons and positrons, circulating in opposite directions, to study their collisions.

ADONE's experiments revolved around quantum electrodynamics (QED) tests, proton and neutron form factors, muon study and multihadron production.

It had been designed to operate at Φ resonance, with incredibly intense beams, to search the CP violation in K neutral mesons (KLOE experiment).

At the same time some of the LNF researchers took part in important foreign experiments: at CERN, in US laboratories (Fermilab, SLAC, Jefferson Lab), in Hamburg and recently even in Beijing and Japan.

At LNF, thanks to the presence of high technology support services, the experimental activity also takes on the design and development of detectors meant to be employed both at the local experiments and the external ones.