It flows from west to east in agricultural environments and watered streams including : This small river runs through the Safari Park of Hemmingford township, in the row "9th Concession South Area", heading north, then east to cross the Quebec Autoroute 15.

It passes through the village of Lacolle by a large coil, then flows into the Richelieu River by its western shore, 4.8 kilometres (3.0 mi) north of the border Canada – United States.

Sector Lacolle River served as the first line of defense of Montreal in 1812 as British, Canadian and Mokawks faced the American soldiers defending the border of Canada.

In 1733, a manor of two leagues front (9.6 miles) deep with three (14.4 km) on the Richelieu River, is granted to Louis Denys de La Ronde (1675 to 1741).

The course of the river "la colle" (the glue) appears on two cards from the late French Regime, the one compiled by Nicolas Bellin (1744) and the other by Franquet (1752).