Lacryma Christi was mentioned in the book by Alexandre Dumas, The Count of Monte Cristo, in W. J. Turner's poem Talking with Soldiers, in Candide by Voltaire, and by Christopher Marlowe in his play Tamburlaine the Great, Part II.
In the short story "Rappaccini's Daughter" collected in Mosses from an Old Manse by Nathaniel Hawthorne, a glass of lachryma is drunk by the protagonist "which caused his brain to swim with strange fantasies".
In The Great Warrior Skanderbeg, a Soviet-Albanian production of 1953, the wine is mentioned as a symbol of feudal luxury enjoyed by sybaritic enemies of the protagonist, the popular and prudent ruler of Albania who defeated Venice in the 1447-48 war and stalled the advance of the Ottoman Empire.
In the title story of Ray Bradbury's 1964 collection The Machineries of Joy, an Irish priest squabbles with his Italian colleague over space travel and its place in their faith; the two clerics reconcile over a bottle of Lacryma Christi while watching a televised rocket launch from Cape Canaveral.
In Jacques Rivette’s 1976 film Duelle, the drink order “Lacryma Christi” is used as a password to gain entry to a casino above a bar, first by the Sun Goddess, Viva, and then by Lucie, the hotel night porter and amateur private detective tailing her.