In 1815 at Clifton, Bristol, Mary married Wyndham Lewis, MP (1780–1838), a colleague of Benjamin Disraeli.

In August 1839, the year following Lewis's death, she married Disraeli at St George's, Hanover Square, in London.

[3] Even Queen Victoria herself was said to be amused when Mary Anne commented, in response to a remark about some lady's pale complexion, "I wish you could see my Dizzy in his bath!"

In November she felt well enough to hold a small dinner party for their close friends; but her condition deteriorated and she died on 15 December, at the age of eighty.

In The Prime Minister, a 1941 British historical film starring John Gielgud as Disraeli, Mary was portrayed by Diana Wynyard.

[14] The miniseries was presented in the U.S. on PBS's Masterpiece Theatre in 1980[15] and was nominated for the Emmy Award for Outstanding Limited Series.