Keith Giffen, breakdown artist for 52, commented that Lady Styx was created to be a villain similar to Darkseid, who they felt was overused.

In 52, it is implied that Lady Styx put a bounty on Starfire, Adam Strange, and Animal Man,[2] DC heroes who had been stranded in space following the events of Infinite Crisis.

The resulting battle leads to the apparent death of Animal Man via a necrotoxin (though he was later resurrected by the aliens who originally gave him his powers).

In the 2006 Omega Men miniseries, Lady Styx appears as the central antagonist, seeking powerful artifacts known as "heartstones" in her attempt to remake the universe and usurp the role of God.

On Earth, there have been random outbursts of people acting homicidal and psychopathic, and on Rann, the public has become supportive of their new hero, an Earthman named Champ Hazard, and his destructive and violent ways.