[2] The player takes the role of an 18-year-old woman, who is manipulated by her twin brother to impersonate him during a senior class cruise, where she is to win a popularity contest.

[9] Hardcore Gamer's Marcus Estrada noted the high-quality art, writing and soundtrack, as well as the game's "incredible cast of characters".

[6] Writing for Kill Screen, Jess Joho highlighted Ladykiller in a Bind's "incredible accomplishment" of making consent – which is central to the game's erotic scenes – sexy by making "the most titillating parts show nothing more and nothing less than two people consenting, telling each other what they want with an unwavering honesty and understanding".

[10] In Rock, Paper, Shotgun, Kate Gray wrote that it was "incredibly refreshing to see a game that’s not aimed by default at guys and straight people", but she criticized the game's narrative for undermining the idea of consensuality by having the protagonist lie to her partners about her gender and identity, and as "irresponsible and damaging" for at times blurring the line between consensual BDSM acts, and forced or transactional sex.

[11] After one of the scenes at issue was changed by a patch, Simone de Rochefort and Merritt k at Polygon considered the discussion about it "disheartening" in that it indicated the demand for "an impossible level of precision when dealing with messy topics, especially from queer developers".