The lake lies within the Clay Belt, a vast tract of fairly flat land with fertile soil covering 180,000 km2 (69,000 sq mi) in northwest Quebec and northeast Ontario.

[5] Lake Blouin played a key role in the development of Val-d’Or and the gold mines on which its economy is based.

[10] In 1949, a daily flight, using amphibious aircraft landing on Lake Blouin, linked Val-d’Or to Montreal.

[11] Lake Blouin was also for a brief period used for timber rafting logs from the Val-d’Or area to the sawmill in Amos.

[13] Lake Blouin is featured in a popular song by Val-d’Or native Raôul Duguay called "La bitt à Tibi".