The lake adjoins Vulkathunha-Gammon Ranges National Park to its west and lies adjacent to Lake Callabonna linked by Salt Creek to its north, the southern Strzelecki Desert to its east, and the Frome Downs pastoral lease to its south.

Public road access to the lake is limited to a single, rough four-wheel drive track which commences from the Vulkathunha-Gammon Ranges National Park headquarters at Balcanoona (Virlkundhunha) station 30 kilometres (19 mi) west.

The route to Lake Frome traverses flat, stony terrain following Balcanoona Creek through the only completely protected arid catchment in Australia.

[5] After crossing both the Moomba-Adelaide natural gas pipeline and the dingo fence the track passes over low sand dunes before arriving at the western shore of the lake.

[6] Munda forms part of the local Dreaming story told by the Adnyamathanha people explaining how the region's geology and species originated.