Lake Lewis is an ephemeral salt lake in the Northern Territory of Australia located in the locality of Anmatjere[1] about 170 kilometres (110 mi) north-west of the town of Alice Springs.

[2] The lake system encompasses a number of different terrains, including large areas of saltpans and claypans.

Lake Lewis is bounded in the north by Stuart Bluff Range.

Warburton's expedition in 1873 from the Northern Territory to the Oakover River in Western Australia.

[1] Lake Lewis is also an important site for birds with Black-winged Stilts and Grey Teals, both uncommon species in the Northern Territory, being known to visit the lake.