State Route 564 (SR 564) is an east–west highway in Clark County, Nevada, in the southeast portion of the Las Vegas Valley.

State Route 564 begins as a continuation of the Las Vegas Beltway, starting where I-215 ends at its junction with I-11, which is concurrent with US 93 and US 95.

From there, the route travels east along Lake Mead Parkway, a major arterial roadway, towards downtown Henderson and intersects the Boulder Highway (SR 582).

SR 564 continues northeast through Henderson's residential neighborhoods and turns east just west of Lake Mead National Recreation Area.

SR 564 enters the park, at a point southeast of Lake Las Vegas, and terminates at the end of state maintenance, while the road continues east.