The highway is currently known as Saint Rose Parkway, but was known as Lake Mead Drive prior to 2001.

Originally, it was a 19 mi (31 km) route that began at the current western terminus at Interstate 15 and crossed Boulder Highway in Henderson before ending at the intersection of North Shore Road near Lake Mead.

Since the Nevada Department of Transportation (NDOT) does not co-sign state routes along Interstate highways, the decision was made in 1999 to officially truncate SR 146 to its current eastern terminus.

[1] The portion of the highway east of I-515/US 93/US 95 was recommissioned as State Route 564 (and has since been renamed Lake Mead Parkway).

Clark County posted SR 146 signs along the 6-mile (9.7 km) overlapping section of I-215, even though the state highway designation no longer existed in this section when the freeway was completed in 2001—Many SR 146 signs still remained on I-215 in 2007, but have since been removed.