The eastbound Lake Shore Limited ended on October 28, 1956, as part of a system-wide reorganization.

[1]: 31–35 The westbound Lake Shore Limited originated at Grand Central Station in New York and traveled along the Hudson River to Albany, where it joined with a section from Boston.

From Buffalo it ran over the tracks of the Lake Shore & Michigan Southern Railway (LS&MS) through Cleveland, Ohio, to Chicago's LaSalle Street Station.

[5]: 224–225 On April 19, 1940 the westbound Lake Shore Limited derailed due to excessive speed on a curve killing 31 and injuring nearly 140.

[8]: 266  Amtrak now operates the Lake Shore Limited between Chicago and New York, with a Boston section, over the same route.