Lancaster is a city in Schuyler County, Missouri, United States.

[5] Lancaster is part of the Kirksville Micropolitan Statistical Area.

[6] According to one tradition, the community was named after Lancaster, Ohio, the former home of a first settler.

[7] The William P. Hall House was added to the National Register of Historic Places in 1975.

[10] At the 2010 census there were 728 people, 326 households, and 187 families living in the city.

At the 2000 census there were 737 people, 319 households, and 203 families living in the city.

The racial makup of the city was 99.46% White, 0.14% Native American, 0.14% Pacific Islander, 0.27% from other races.