Brancaccio first emerges in a record of his creation as Cardinal-Deacon by Pope Celestine V in the Consistory of 18 September 1294, and assignment to the Deaconry of Sant'Angelo in Pescheria in Rome.

[6] He was present, however, at Agropoli near Salerno when Queen Blanche of Aragon gave birth to a son and heir, Alfonso; the Cardinal wrote immediately to King James II on 8 September 1299.

In September 1301 Pope Boniface made Cardinal Brancaccio Auditor (Judge) in the matter of the election of a Bishop for his newly acquired territory of Murcia.

[10] When Bishop Hector of the diocese of Castro died, and two candidates were separately elected his successor, the case was referred to the Pope.

[12] At the request of Cardinal Landolfo, his nephew Berardus Sui Sari was granted a canonry and benefice in the Cathedral of Naples on 3 November 1303.

[16] At the end of the reign of Boniface VIII, the Cardinal was entrusted with handling the case of the excommunication of Otto and Conrad of Brandenburg and their followers, who had despoiled various churches and other property, and his recommendations were finally approved by Benedict XI on 12 March 1304.

He died in Avignon of 29 October 1312, and was buried in the Cathedral of Notre Dame des Domps, in the Chapel of the Angels which he had had constructed.