The first Lane's opened at the corner of Adams and Erie Streets in Downtown Toledo, across from the Lucas County courthouse, in 1922.

In 1938, Lane's opened its first air conditioned superstore on Sylvania Avenue allowing customers the convenience of self-service and a soda fountain.

[citation needed] Lane's built a warehouse at Detroit and Dura Avenues in Toledo in 1952, in anticipation of future expansion in the area.

[2] By 1961, additional locations included Parkway Plaza in Maumee, Ohio, Starr Avenue and Woodville Road in East Toledo, 1320 Dorr, 5233 Dorr, 3411 Monroe, 1028 Sylvania, Swayne Field, and Westgate in West Toledo, and S. Main St. in Bowling Green.

[3] In 1968, a 7,000-square-foot (650 m2) store was opened in Rossford, Ohio featuring "lighted glassware displays of the latest merchandising design".

At that time the company operated 106 drug stores in five states, including Ohio, Pennsylvania, West Virginia, Alabama, and Georgia.

[22] In March 1970, the Parkway Plaza store in Maumee was cited by the United States Department of Labor for not meeting minimum wage standards with its 15 employees.

The union (now known as the United Food and Commercial Workers) still represents employees in the Rite Aid "Lane’s" stores.

[30] In 1971, Lane's ran a full-page ad showcasing personalized service, with a photo of the pharmacists in each of 24 Toledo area stores, their names and alma mater.

[32] By 1979, Lane's grand openings were spectacles, with festivities including clowns, beauty consultants from major cosmetics companies, beauty queens, college football heroes, Indy cars, free samples, free cigars, fragrances, and balloons, $5 prescription "Medi-Bucks", and local marching bands.

[7][8] In the mid-1980s, Lane's used the slogan "We’re ready", and advertising showcased services such as the convenience of 52 locations in metropolitan Toledo, professionalism of pharmacists, generic prescription savings, senior citizen discounts, baby club, award-winning health information pamphlets, extended business hours, computerized pharmacy data systems, and 6 optical centers with eye exams available at the Southland location.

[33] In 1988, TV and radio ads ran for Lane's (later using the People's name) featuring Dixie Carter and Annie Potts from the then-popular "Designing Women" television series.