There is a severe underdevelopment or complete absence of the ulna and fibula (hypoplasia or aplasia), along with a thickened and curved radius and tibia.
Additionally, these anomalies can lead to deformities of the hands and feet, and there may be hypoplasia of the lower jaw as well.
[1][2] Diagnosis may be suspected on the basis of the clinical and radiologic findings, which are already present at birth, and can supported by molecular analysis of the SHOX gene.
[citation needed] Children with Langer mesomelic dysplasia are given Growth hormone; it does not affect the bone anomalies, but it can increase the final height reached by 7 to 10 cm.
[3][4] In selected patients, orthopaedic surgery may be helpful to try to gain some functionality of severely impaired joints.