Through her mother’s previous marriages, she had various maternal half-brothers and sisters and two full blooded brothers who served as Seleucid kings Antiochus V Eupator and Alexander Balas.
In 152 BC, Laodice became one of the supporters for her brother Alexander Balas, who revolted and overthrew the Seleucid king Demetrius I Soter, who was their maternal half-brother/cousin.
Nysa, Roxana and Statira were put to death after the fall of the Kingdom of Pontus in 63 BC.
Mithridates V was assassinated in about 120 BC in Sinope poisoned by unknown persons at a lavish banquet which he held.
He was able to remove his mother and his brother from the Pontian throne, thus Mithridates VI became the sole ruler of Pontus.