[1] Lapidaria margaretae resembles those genera within the family Aizoaceae to which it is most closely related; namely Lithops, Dinteranthus and Schwantesia.

[1] This species is native to dry areas (250 mm per year) in southern Namibia, around Warmbad and the Northern Cape areas adjacent to Warmbad in South Africa, at an elevation of 660 to 1,100 metres (2,170 to 3,610 ft) above sea level.

Lapidaria margaretae grows on white quartz plains, in crevices, in red sand or on loose stone.

It is usually located on Northeast-facing gentle hill slope in full sun, or under dwarf shrub in a succulent steppe.

They need full bright sunlight throughout the year and will grow at any time when the weather is warm and sunny and water is available.