Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree.
It is currently considered to be a subtype of large-cell lung carcinoma.
LCNEC is often generically grouped among the non-small-cell lung carcinomas.
[2] The World Health Organization classification of lung tumors[1] recognizes a variant of LCNEC, namely "combined large-cell neuroendocrine carcinoma" (c-LCNEC).
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