The station was originally opened as Larkhall Central on 1 July 1905 by the Caledonian Railway as part of their Mid Lanark Lines which filled in various gaps around Larkhall, Stonehouse, Strathaven and Blackwood.

Forty years after closure, the station was officially reopened on 9 December 2005 by Jack McConnell MSP, the then First Minister for Scotland.

Passenger services started on 12 December 2005, with trains serving the Argyle Line.

From opening in December 2005, trains run every 30 minutes to Glasgow Central and beyond to Dalmuir.

[2] An hourly Sunday service started from December 2007 on a one-year trial basis.