Larkinsville is a historic village and populated place in Jackson County, Alabama, United States.

A post office was established in 1830, with David Larkin as postmaster, and Larkinsville became the most populous town in Jackson County up until the Civil War.

[11] As a stop along the strategically important railroad, Larkinsville would be occupied by Union forces for the remainder of the war, including the 13th Wisconsin,[12] the 10th Iowa,[13] the 116th Illinois,[14] and the 101st U.S.

[15] The postwar establishment of the county seat at Scottsboro began a gradual movement of people and business away from Larkinsville.

[16] The railroad kept the village alive into the 1930s, but Alabama State Road 35 and U.S. 72, the main east-west highways in Jackson county, bypassed Larkinsville entirely.