Larrys Creek is a 22.9-mile-long (36.9 km)[7] tributary of the West Branch Susquehanna River in Lycoming County in the U.S. state of Pennsylvania.

The creek flows south from the dissected Allegheny Plateau to the Ridge-and-valley Appalachians through sandstone, limestone, and shale from the Devonian, Mississippian, and Pennsylvanian periods.

In the 19th century, the creek and its watershed were a center for logging and related industries, including 53 sawmills, grist mills, leather tanneries, coal and iron mines.

Roaring Run receives the only acid mine drainage in the watershed and enters Larrys Creek 10.4 miles (16.7 km) from the mouth.

Larrys Creek then enters Piatt Township, flowing east around a ridge and through the village of Larryville where it receives Seeley Run on the left bank, 1.5 miles (2.4 km) from the mouth.

It next flows back southwest, then south to the hamlet of Larrys Creek and finally into the West Branch Susquehanna River, 2.6 miles (4.2 km) east of the borough of Jersey Shore, at an elevation of 515 feet (157 m).

[2] From 1960 to 1979, the United States Geological Survey (USGS) operated one stream gauge on Larrys Creek at the village of Cogan House, for the uppermost 6.8 square miles (18 km2) of the watershed.

[23] Larrys Creek is in a sandstone, limestone, and shale mountain region, with the source in the dissected Allegheny Plateau and the mouth in the Ridge-and-valley Appalachians.

[25] Iron ore within the watershed was mined south of Salladasburg and along Canoe Run in the 19th century; there are also deposits on Puterbaugh Mountain.

The only named peak on the west bank of Larrys Creek itself is Harris Point, where it leaves the dissected Allegheny Plateau.

[29] The Larrys Creek watershed has two deposits of low volatile bituminous coal along Roaring Run[30] and a small, deep natural gas field.

[31] A potentially large source of natural gas is the Marcellus Shale, which lies 1.5 to 2.0 miles (2.4 to 3.2 km) below the surface here and stretches from New York through Pennsylvania to Ohio and West Virginia.

[32][33] In November 2007, drilling within the Larrys Creek watershed started in Mifflin Township, just west of Salladasburg, with a 1.5 miles (2.4 km) deep well.

[36] The Marcellus Shale requires special techniques to fracture the rock and release the gas, including pumping sand and water into the well, and, in some cases, horizontal drilling.

"Camp Kiwanis" has a main lodge, four cabins, picnic pavilion, and various recreational facilities on 50 acres (20 ha) on Route 287, 1.0 mile (1.6 km) south of Salladasburg in Mifflin Township.

[44] It is operated as a service by the Williamsport Kiwanis and rented out for fire department training, Girl Scouts, weddings, church, and other groups.

Further south along the creek in Piatt Township is the New Tribes Mission camp for preparing Christian missionaries for field work with indigenous peoples in remote parts of the world.

[45][46] Edward Gertler writes in Keystone Canoeing that Larrys Creek "has an exceptionally scenic, ultra-highwater, whitewater run that is really worthy of your attention".

[10] Canoeing and kayaking on Larrys Creek are possible when the water is high enough (in Spring and after hard rain), with 8.0 miles (12.9 km) of Class 3 whitewater on the International Scale of River Difficulty from Township Road 786 south through the State Game Lands to Route 973, and 7.4 miles (11.9 km) of Class 1 to 2 whitewater south from PA 973 to U.S.

The largest is the "Larrys Creek Fish and Game Club", incorporated August 1, 1906, which owns over 6,000 acres (2,400 ha) along Route 287 on the Second Fork.

[52] Another large private club is the Ogontz Lodge on the First Fork, established by banker Jay Cooke about 1884 for fishing and hunting.

[54] Herbert Hoover found solitude at the Ogontz Lodge as a guest of Jay Cooke III three times: in June, 1918 (just before leaving for Europe as head of the American Food Administration), mid-May, 1928 (just before his selection as the Republican presidential candidate), and finally in late May, 1930 (as President of the United States).

[54][56] Two Clovis points found in the Salladasburg area in a "stream site" are the earliest evidence of human activity along Larrys Creek (circa 10,000 BCE).

The lands of the West Branch Susquehanna River Valley were then chiefly occupied by the Munsee phratry of the Lenape (or Delaware), and were under the nominal control of the Five (later Six) Nations of the Iroquois.

Larrys Creek was in the disputed territory between these, so the illegal settlers there were part of the "Fair Play Men" system of self-government, with their own Declaration of Independence from Britain on July 4, 1776.

Homes and fields were abandoned, with livestock driven along and a few possessions floated on rafts on the river east to Muncy, then further south to Sunbury.

On May 2, 1872, a large forest fire destroyed the villages of Carter and Gould, 6 miles (9.7 km) north of Salladasburg on Larrys Creek in Mifflin Township.

It was still an active corporation in 1865, but the charter of the "Jersey Shore, Pine Creek and Buffalo Railway" in 1870 (New York City-Reading interests) superseded it.

[61] The Cogan House Covered Bridge was the only one on Larrys Creek to survive the flood, as a fallen tree formed a protective dam just upstream.

[66] The 90 foot (27 m) long Burr arch truss bridge was built in 1877, listed on the National Register of Historic Places in 1980, rehabilitated in 1998, and is today one of just three left in the county.