Lycoming Creek, which begins in McNett Township, served as a highway of sorts during the colonial era of Pennsylvania's history.
The local Lenape (Delaware) people called it Legani-hanne, meaning "sandy stream" - the name was later rendered by Europeans as Lycaumick and then Lycoming.
Conrad Weiser guided Moravian missionaries along the creek and path to reach Onondaga, the capital of the Iroquois Confederacy in 1737.
Colonel Thomas Hartley led the 6th Pennsylvania Regiment up the Sheshequin Path during the American Revolution.
Both Hartley and Sullivan were instrumental in claiming the frontier of Pennsylvania and New York for the forces of the Continental Army.
Six people died as a result of flooding on Lycoming Creek in the greater Williamsport area, and there was millions of dollars of damage to property.