The year 1939 saw the introduction of Rolling Rock beer (famous for its small green bottles) and Latrobe became one of the largest breweries in the United States.

[3] On June 21, 2006, InBev signed a letter of intent with City Brewing Company from La Crosse, Wisconsin, "giving it exclusive rights for an undetermined time to negotiate a purchase of the plant."

[6] In late October 2008 City Brewery-Latrobe laid off 70 workers, forcing a temporary shutdown, and had not brewed beer at the plant since November.

[11] In July 2009 some Southampton brands (Double White, IPA, Altbier, Pumpkin, Imperial Porter) were moved to Latrobe from Lion Brewing.

In 2012, Diageo moved production of the U.S. supply of Red Stripe from Jamaica to the U.S., with City Brewing Company making the beer in their Latrobe brewery.