Laura Gagliardi (born 6 April 1968) is an Italian theoretical and computational chemist and the Richard and Kathy Leventhal Professor of Chemistry and Molecular Engineering at the University of Chicago.

She is known for her work on the development of electronic structure methods and their use for understanding complex chemical systems.

She was also the director of the Chemical Theory Center from 2011 to 2020 at the University of Minnesota.

[1] In 2020, she joined the University of Chicago as the Richard and Kathy Leventhal Professor in chemistry and molecular engineering.

Gagliardi is married to Christopher J. Cramer; the couple has three children from a prior marriage.