[9][10] Growing up, Vandervoort was involved in several sports such as football, karate (where she is a second-degree black belt),[1][2][8] basketball, tennis, gymnastics and baseball.

[2] After commercials and guest starring roles in Mutant X, Prom Queen: The Marc Hall Story, Goosebumps, Twice in a Lifetime, Doc, Sue Thomas: F.B.Eye, Troubled Waters, The Dresden Files, and a few Disney Channel original films (Mom's Got a Date with a Vampire and Alley Cats Strike), at age 19, while attending York University[12] where she studied Psychology and English,[1] Vandervoort landed a lead role as Sadie Harrison in the CTV teen drama series Instant Star, which ran for four seasons.

[2][12] In 2006, Vandervoort starred in her first feature film titled The Lookout alongside Jeff Daniels, Joseph Gordon-Levitt, Matthew Goode, and Isla Fisher.

[2][4][5][8] In 2010, Vandervoort appeared in the two-part miniseries Riverworld in which she plays Jessie Machalan, the fiancée of war correspondent Matt Ellman who wakes up after death on a planet populated by everyone who has ever lived on Earth.

[2][14] In October 2011, she posed for PETA as part of the "Exotic Skins" campaign[15] and in 2014, she appeared nude again for an ad that protested against the keeping of marine mammals in captivity.

In 2019, Vandervoort appeared in the Netflix adaptation of the Jonathan Maberry book series V Wars alongside Ian Somerhalder, Adrian Holmes, and Peter Outerbridge, premiered on December 5, 2019.