She was a researcher at the Centre d'Etudes Prospectives et d'Informations Internationales (CEPII) from 1996 to 1998, then an economist at the department of Economic Affairs of the OECD from 1998 to 2004.

[8] The announcement of her nomination to President François Hollande was made in early June 2014[4] as an anticipation of Emmanuel Macron's resignation.

[10] The announcement of her nomination also sparked harsh comments, like the one of Slate's Éric Dupin [fr]: "the world of finance that governs without ever having been elected"[11] —which is a reference to François Hollande's 22 January 2012 speech in Le Bourget.

[13] On 26 December 2014 Boone's position was named "special advisor for multilateral and European economic and financial affairs", sherpa of François Hollande, as a part of a series of decisions made to "simplify" his cabinet.

[24] In June 2021, Boone was also appointed to the World Bank–International Monetary Fund High-Level Advisory Group (HLAG) on Sustainable and Inclusive Recovery and Growth, co-chaired by Mari Pangestu, Ceyla Pazarbasioglu, and Nicholas Stern.

[25] In January 2022, Boone was appointed as Deputy Secretary-General of the OECD, serving alongside Kerri-Ann Jones and Ulrik Knudsen under secretary general Mathias Cormann.