[13][14][15][16][17][18][19][20] Lawrence High School offers numerous honors and Advanced Placement (AP) classes including Biology, Calculus, Chemistry, Economics, English, Environmental Science, European History, Music Theory, Physics, Statistics, Studio Art, United States Government and Politics, and United States History.

[26] The school's most successful teams include football, golf, wrestling, soccer, swimming, diving, tennis, softball, cheerleading and cross-country.

The co-op program operates under agreements scheduled to expire at the end of the 2023–24 school year.

[28][29] The program won its first state title in 1967 with a 3–2 win against Northern Highlands in the Group II championship game.

The 1974 football team, featuring future NFL quarterback Scott Brunner, was overshadowed by a defensive unit that had eight shutouts and only allowed six points all year, with a record of 8-0-1, as part of a three-year undefeated stretch from 1972 to 1974 in the pre-playoff era where the team won 21 games and had one tie.

In 2006, the team made it to the state playoffs as the top seed, only to be knocked off by 8th-seeded Moorestown High School at home 19–14 in the first round of the tournament.

[34] In 2007, the team made it to state playoffs once again but were defeated by Middletown South at home in the first round, 16–6.

Lawrence Girls track and field team were the 2014 CVC Patriot Division Co-Champions.

[43] In 2019, the tennis team won the Group II state championship with a 3–2 win against Northern Valley Regional High School at Demarest in the tournament final.

Lawrence High School also has a DECA chapter and is active in the New Jersey Science Olympiad.

These clubs wrote a co-grant and received $8,437 for their grant to build computers and engineer a go-kart.

Lawrence High School's mock trial team, led by history teacher Mark Rowe and local attorney Steve Goodell, has won 11 Mercer County Competitions and six Central Jersey Championships.