Lawrence James DeLucas is an American biochemist who flew aboard NASA Space Shuttle mission STS-50 as a Payload Specialist.

DeLucas attended the University of Alabama at Birmingham as an undergraduate and graduate student, receiving doctorates in optometry and biochemistry in 1981.

DeLucas was a member of the crew of Space Shuttle Columbia for STS-50 (June 25-July 9, 1992), the United States Microgravity Laboratory-1 (USML-1) Spacelab mission.

Over a two-week period, the crew conducted a wide variety of experiments relating to materials processing and fluid physics.

At mission conclusion, DeLucas had traveled over 5.7 million miles in 221 Earth orbits, and had logged over 331 hours in space.