[2] Krauss is the author of several bestselling books, including The Physics of Star Trek (1995) and A Universe from Nothing (2012), and chaired the Bulletin of the Atomic Scientists Board of Sponsors.

In 2006, Krauss led the initiative for the no-confidence vote against Case Western Reserve University's president Edward M. Hundert and provost John L. Anderson by the College of Arts and Sciences faculty.

[11] In August 2008, Krauss joined the faculty at Arizona State University as a foundation Professor in the School of Earth and Space Exploration at the Department of Physics in the College of Liberal Arts and Sciences.

As a result of his appearance in 2002 before the state school board of Ohio, his opposition to intelligent design has gained national prominence.

He served on the science policy committee for Barack Obama's first (2008) presidential campaign and, also in 2008, was named co-president of the board of sponsors of the Bulletin of the Atomic Scientists.

[16] In 2013, he accepted a part-time professorship at the Research School of Astronomy and Astrophysics in the physics department of the Australian National University.

[21][22] The paperback version of the book appeared in January 2013 with a new question-and-answer section and a preface integrating the 2012 discovery of the Higgs boson at the Large Hadron Collider.

[23] In January 2019, Krauss became President of the Origins Project Foundation,[24] a non-profit corporation intended to host public panel discussions on science, culture, and social issues.

[27] As his model appears to agree with experimental observations of the Universe (such as its shape and energy density), it is referred to by some as a "plausible hypothesis".

Krauss is featured in the 2013 documentary The Unbelievers, in which he and Richard Dawkins travel across the globe speaking publicly about the importance of science and reason as opposed to religion and superstition.

[45] In 2006, Krauss helped to organize a conference on gravity, funded by a foundation of financier and later convicted sex offender Jeffrey Epstein.

"[55][56] Case Western Reserve responded to the student complaint by restricting Krauss's access to campus, although by the time the sanctions began he had already left for ASU.

[54] ASU stated that they had not received complaints from faculty, staff, or students before the BuzzFeed article but subsequently began an internal investigation regarding an accusation that Krauss grabbed a woman's breast while at a convention in Australia.

The woman told investigators that "she did not feel victimized, felt it was a clumsy interpersonal interaction and thought she had handled it in the moment.

"[4] ASU found that the preponderance of evidence suggested that Krauss had violated the university's policy against sexual harassment by grabbing a woman's breast without her permission.

[61][62] Following the ASU investigation, Krauss was placed on paid administrative leave starting in March of 2018 and was recommended for dismissal by the dean of the department.