Le Fresne-sur-Loire (French pronunciation: [lə fʁɛn syʁ lwaʁ], literally Le Fresne on Loire; Breton: Runonn) is a former commune of the Loire-Atlantique department in western France.

On 1 January 2016, it was merged into the new commune of Ingrandes-le-Fresne-sur-Loire, and became part of the Maine-et-Loire department.

[2] It is around 25 km west of Angers, and around 50 km east of Nantes.

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