It includes all communities along the Gulf of Saint Lawrence between the Natashquan River and the Newfoundland and Labrador border.

It has a total area of 48,146.88 square kilometres (18,589.61 sq mi) according to Quebec's Ministère des Affaires municipales, des Régions et de l'Occupation du territoire (which includes coastal, lake, and river water territory),[3] and a land area of 40,686.75 square kilometres (15,709.24 sq mi) according to Statistics Canada.

[6] Le Golfe-du-Saint-Laurent Regional County Municipality is characterized by the absence of road connections between the villages that are spread out along its 375 kilometres (233 mi) shoreline of the gulf.

Except for Blanc-Sablon, all communities are only accessible by boat or plane, although Quebec Route 138 is being planned to extend all along the coast.

There are a number of large rivers that flow in a generally north–south direction through Le Golfe-du-Saint-Laurent to enter the Gulf.