Lead-DBS

Lead-DBS is an open-source toolbox for reconstructions and modeling of Deep Brain Stimulation electrodes based on pre- and postoperative MRI & CT imaging.

Lead-DBS was originally developed at the Charité Berlin beginning in 2012 by Andreas Horn and has been freely available for research use under the GNU General Public License since 2014.

[2] Funding for continued development included an Emmy Noether award by the German Research Foundation[3] as well as an R01 grant by the National Institute of Mental Health.

[11] Regarding the open-source nature of the software, Latorre and colleagues reported that 'A commitment of the community to open science will also democratize and increase the speed of advances with high uptake of currently available initiatives such as Lead-DBS'.

[12] The software has been used in a prospective clinical trial[13] which showed that subthalamic stimulation settings in patients with Parkinson's disease which were generated with Lead-DBS were non-inferior to standard of care treatment.

Electrode reconstruction generated with Lead-DBS. The picture shows two electrodes implanted into the subthalamic nucleus (orange) for treatment of Parkinson's disease. Other structures: Stimulation volumes (red), internal (green) and external (cyan) parts of the pallidum.