Due to sensitivity and stability concerns, the dextrinated form of lead azide (MIL-L-3055) was developed in the 1920s and 1930s with large scale production by DuPont Co beginning in 1932.

[10] Detonator development during World War II resulted in the need for a form of lead azide with a more brisant output.

[14] Lead azide was a component of the six .22 (5.6 mm) caliber Devastator rounds fired from a Röhm RG-14 revolver by John Hinckley, Jr. in his assassination attempt on U.S. President Ronald Reagan on March 30, 1981.

The rounds consisted of lead azide centers with lacquer-sealed aluminum tips designed to explode upon impact.

A strong probability exists that the bullet which struck White House press secretary James Brady in the head exploded.