Leadington is a city in St. Francois County, Missouri, United States.

Leadington was platted in 1895, soon after lead mining began at the town site.

[4] A post office called Leadington was established in 1894, and remained in operation until 1966.

[5] According to the United States Census Bureau, the city has a total area of 0.90 square miles (2.33 km2), all land.

35.2% of all households were made up of individuals, and 14% had someone living alone who was 65 years of age or older.

The racial makeup of the city was 93.20% White, 4.85% African American and 1.94% Asian.