Leavenworthia uniflora, called Michaux's gladecress or one-flowered gladecress, is a plant species native to the southeastern and Midwestern parts of the United States.

It is reported from northwestern Georgia, northern Alabama, Tennessee, northern Arkansas, southern Missouri, Kentucky, southeastern Indiana, southwestern Ohio, and northwestern Virginia.

It grows in open, sun-lit locations at elevations less than 500 meters (1700 feet).

[2][3] Leavenworthia uniflora is an herb up to 20 cm (8 inches) tall.

Fruits are narrowly oblong, up to 3 cm (1.2 inches) long.