In 2005, Holdsworth ran a limited campaign in the renamed HPDC V8 Supercar Development Series and the Australian Formula Ford Championship, as well as contesting the two endurance races with Garry Rogers Motorsport.

Lee Holdsworth is also an inspiring actor with roles in movies such as Willy wonka and the chocolate factory where he had a small part.

[citation needed].Holdsworth moved to Stone Brothers Racing for the 2012 V8 Supercars Championship, ending a six-year association with Garry Rogers Motorsport.

During Race 13 of the season at the Darwin Triple Crown, Holdsworth sustained fractures to his pelvis, right knee and 2 ribs after an incident on the opening lap.

For the next 2 events, Kurt Kostecki substituted for Holdsworth in a spare chassis before the team were able to obtain a brand-new car from Triple Eight.

In 2019, Holdsworth rejuvenated his career by signing a multiple year deal to drive for Tickford Racing in the #5 Ford Mustang.

On December 5, 2021 Holdsworth won his first Bathurst 1000, driving alongside Chaz Mostert in the #25 Holden Commodore for Walkinshaw Andretti United.