It has an accident and emergency department, womens' hospital, paediatrics, oncology (including radiotherapy) and other specialisms.

[3] St Luke's Chapel, which benefited from extensive stained glass windows and memorials, was built in 1887.

[6] Dr. Hadiza Bawa-Garba, a junior doctor at the Infirmary, was convicted of manslaughter for her part in the death of a 6-year-old boy from sepsis and received a suspended prison sentence in 2015.

[7] A congenital heart centre opened at the Kensington Building at the Leicester Royal Infirmary in August 2021.

This unit, which was transferred from Glenfield Hospital with support from Pick Everard,[8] forms part of the East Midlands Congenital Heart Network.