The genus Leiopython contains the following species: Nota bene: A binomial authority in parentheses indicates that the species was originally described in a genus other than Leiopython.

Female adults of the northern white-lipped python (L. albertisii) grow to an average of about 213 cm (6–7 ft) in total length (including tail), whereas the southern white-lipped python (L. fredparkeri) can reach up to 300 cm (9.8 ft) in total length.

[5] Although mostly terrestrial, snakes of the genus Leiopython can and are known to occasionally climb.

[6] White-lipped pythons are reportedly aggressive, though this is reduced in those born and raised in captivity.

[7] These snakes have also been observed to regularly regurgitate fur balls from their prey.