Leo Apostyppes or Apostoupes (Greek: Λέων ὁ Ἀποστύππης/Ἀποστούπης) was a Byzantine military leader active in the 880s.
He appears in 880, as military governor (strategos) of the themes of Macedonia and Thrace, leading the troops of these two provinces in campaign in southern Italy.
Nevertheless, when Emperor Basil I heard of the events, he dismissed Apostyppes and banished him to house arrest near Kotyaion.
The two sons of Apostyppes, Bardas and David, learned of these accusations and killed Baianos, whereupon they along with Leo tried to flee to the Abbasid Caliphate.
Leo was brought back to Constantinople, where he had an eye and an arm cut off and was banished to Mesembria.