De Guzman is also currently a member of the Board of Trustees of the human rights non-governmental organization PhilRights and Bulig Visayas, another NGO for aiding calamity victims.

De Guzman formed the pro-worker Labor Win coalition for the elections with Neri Colmenares of Bayan Muna, Sonny Matula of the Workers’ Party, independent Allan Montaño, and Ernesto Arellano of Katipunan of Kamalayang Kayumanggi.

Later on October 6, De Guzman filed his certificate of candidacy for president, running on a platform of systemic change including labor issues such as raising minimum wage and abolishing contractualization.

On social issues, De Guzman opposed the return of the death penalty, pushed for stipends for poor students and the implementation of a Universal Basic Income, and supported the legalization of divorce.

He was against passing constitutional change under the Duterte administration towards federalism, the lowering of criminal age of liability, the extension of Martial law in Mindanao, and the phenomenon of red-tagging against activists and unionists.

In 2021, De Guzman reiterated his previous political positions, and included other proposals such as the abolition of the NTF-ELCAC and the repeal of the Anti-Terrorism Law of 2020, among other measures that signaled a "violent regime" as part of a 25-point progressive agenda.

[17][18] He believes that solid positions on the following issues are important if "unification talks" with fellow presidential candidate Vice President Leni Robredo were to be possible:[19][20] Leody is married to Marieza Tolentino with three children: Prolan, Lea, and Dexter.