Leon Crosswhite (born April 28, 1951) is an American former professional football player who was a running back in the National Football League (NFL).

He played college football for the Oklahoma Sooners and was selected in the second round of the 1972 NFL draft.

Crosswhite attended University of Oklahoma and played for the Sooners as a running back in their wishbone formation from 1970 to 1973.

On January 28, 1975, Crosswhite was traded to the New England Patriots.

On September 3, 1975 the Patriots placed Crosswhite on injured reserve.