His books include Art & Physics: Parallel Visions in Space, Time, and Light (1991), The Alphabet Versus the Goddess (1998), Sex, Time and Power: How Women's Sexuality Shaped Human Evolution (2003), and Leonardo's Brain: Understanding da Vinci's Creative Genius (2014).
Prior to his internship at UCSF Medical Center at Mount Zion in San Francisco, he worked for a short time at Bellevue Hospital in New York City.
[5] After he and Carole divorced, Shlain met and married his second wife, Superior Court Judge Ina Levin Gyemant.
They lived in Mill Valley, California where he died on May 11, 2009 (at age 71) after a year long struggle with brain cancer.
[5] The film Connected: An Autoblogography About Love, Death & Technology (2011), directed by Shlain's daughter Tiffany, is in part a portrait of him.