Lepotrema acanthochromidis is a species of lepocreadiid digenean parasitic in the intestine of marine fish.

It was described in 2018.

[1] The spiny chromes, Acanthochromis polyacanthus (Perciformes: Pomacentridae), is the type-host of Lepotrema acanthochromidis.

The type-locality is off Heron Island, Great Barrier Reef, Australia, and another locality is off Lizard Island, Great Barrier Reef, Australia.