Lepotrema amblyglyphidodonis is a species of lepocreadiid digenean parasitic in the intestine of marine fish.

[1] The staghorn damselfish, Amblyglyphidodon curacao, (Perciformes: Pomacentridae), is the type-host of Lepotrema amblyglyphidodonis.

Another host is the Barrier Reef anemonefish, Amphipron akyndynos (Pomacentridae).

The type-locality is off Heron Island, Great Barrier Reef, Australia.

This Trematoda (fluke)–related article is a stub.