It is found in eastern Bolivia and eastwards to Brazil, Paraguay, and Uruguay and southwards to central Argentina.

The dorsum is uniform, striped, or bears small dark spots.

[3] Leptodactylus mystacinus is a terrestrial frog found in grasslands near standing bodies of water, its breeding habitat.

Reproduction takes place in under-ground foam nests; the tadpoles develop in water.

It occurs in several protected areas and is not considered threatened by the International Union for Conservation of Nature (IUCN).