The school is located on the northwestern corner of College Street and University Avenue, placing it across from the Ontario Legislative Building and at the entrance to Queen's Park station.

The Faculty of Pharmacy Building is particularly notable for its two orb-shaped classrooms, referred to as the "pods", which are suspended lecture halls.

The pods are lit at night with coloured stage lights visible from afar, giving the building a "Star Trek feel".

"[2] The Pharmacy Building has received international coverage and awards, in part because of its design team, including world-famous Sir Norman Foster and Claude Engle, as well as its high-profile sponsor Leslie Dan.

As a result, in 1992, the faculty introduced the PharmD (Doctor of Pharmacy) in hopes to accommodate for the growing need for graduates in the field.

This centre will feature enhanced facilities including a one hundred seat classroom, and will allow increased enrolment into the programme.

The building was named the Leslie L. Dan Faculty of Pharmacy Building in 2001 in honour of the generous donation made by Leslie Dan, an alumnus of the school and a noted pharmacist, philanthropist, entrepreneur and Member of the Order of Canada, as well as founder of the generic drug manufacturer Novopharm and the Canadian Medical Aid Programme.

[1][14] During the COVID-19 pandemic, the Leslie Dan Faculty of Pharmacy received a $554,792 grant from the Public Health Agency of Canada's Immunization Partnership Fund to reduce adult vaccine hesitancy through the CARD (Comfort, Ask, Relax and Distract) system previously developed for children.

At the University of Toronto, pharmacy students are already being trained for physical assessments and prescribing rights through problem-based, experiential and student-directed approaches to common ailments, case-based and critical reasoning skills and other coursework in pathophysiology, clinical biochemistry and pharmaceutical care.