Leslie 'Les' Zachary Benet (born May 17, 1937) is an influential pharmaceutical scientist[1] heading the UCSF's Benet Lab at the Department of Bioengineering and Therapeutic Sciences[2] and recipient of the Remington Medal for distinguished service to American pharmacy.

His father, Jonas and his uncle, Harry, opened Benet's Pharmacies in Cincinnati in the 1930s and in 1942 founded DARA Products, the first drug company to manufacture hypoallergenic dermatologicals.

[3] Benet's early work included noncompartmental methods for calculating clearance and volume of distribution.

Benet regularly advised the FDA in proposing guidance in the field of bioequivalence.

[9] His recent work extended the Biopharmaceutics Classification System, leading to the Biopharmaceutics Drug Disposition Classification System allowing the prediction of enzymes and transporters, transporter-enzyme interplay and transporter-transporter interplay for new molecular entities and drug-drug interactions for already marketed drugs.