Lesslie is a census-designated place located in York County, South Carolina, United States, southeast of the city of Rock Hill.

Lesslie is a fast-growing suburban area a part of the Charlotte Metro along Interstate 77, which can be accessed from exits 75 and 77.

Lesslie is located approximately 3 miles (4.8 km) southeast from Rock Hill, at 34°53'25" North, 80°57'23" West.

The coldest temperature in the area was -6 °F while the warmest was 108 °F, both recorded at the Rock Hill Municipal Airport.

As of the 2020 United States census, there were 3,068 people, 1,127 households, and 852 families residing in the CDP.