They have men's and women's teams that compete in U Sports basketball, rugby union, soccer, swimming, and track and field.

The Pronghorns, in partnership with the City of Lethbridge, hosted the 2019 edition of the University Cup at the ENMAX Centre.

[4] The most successful athletic program at the University of Lethbridge is the women's rugby team.

Hortness was selected to become a member of the Canadian National Team and competed in Turkey in August 2005.

At the Alberta Judo Provincials in 2005, Tanner Mair topped the ten other competitors in his weight class to win the gold.